Molecule of the Year 2009
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.
Mátés L, Chuah MK, Belay E, Jerchow B, Manoj N, Acosta-Sanchez A, Grzela DP, Schmitt A, Becker K, Matrai J, Ma L, Samara-Kuko E, Gysemans C, Pryputniewicz D, Miskey C, Fletcher B, Vandendriessche T, Ivics Z, Izsvák Z.
From left to right: Abel Acosta-Sanchez, Prof. Dr. Marinee K.L. Chuah (groupleader - principal investigator), Prof. Dr. Thierry VandenDriessche (groupleader - principal investigator), Eyayu Belay, Dr. Janka Matrai, Ermira Samara-Kuko
Information about the 15 nominees can be found here
The picture was taken at the MDC campus in Berlin and shows members (postdocs,
PhD students and technicians) of the research group "Mobile DNA". The key
persons for SB100X are the 6th from left Lajos Mates, 7th from left Zoltan Ivics
and the 8th from left Zsuzsanna Izsvak.
From the authoring center (auf
den ursprünglichen Deutsch)
A review of some of the challenges involved in stable gene transfer in stem cell research, including a history of Sleeping Beauty
A review on the use of non-viral induction of pluripotent stem cells or for gene therapy
A comment on the application and efficacy of the new construct of Sleeping Beauty Transposase.
An editorial in the journal Human Gene Therapy
A brief breakdown (and an even shorter version) of the work as it relates to gene therapy (In het Nederlands)
Virtually the same article
A short popular press article
An article (Em português)
Excellent choice! Happy New Year
-Dr. Wayne W. Grody, Advisor, ISMCBBPR