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| 2011 | |
 | Bone Morphogenetic Protein 7
A Kobayashi, H Okuda, F Xing, PR Pandey, M Watabe, S Hirota, SK Pai, W Liu, K Fukuda, C Chambers, A Wilber and K Watabe. 2011. Bone morphogenetic protein 7 in dormancy and metastasis of prostrate cancer stem- like cells in bone.
J Exp. Med. 208(13), 2641-2655. Click here for the announcement and for the runners up.
Molecule of the Year 2011 in the limelight- from Biotechniques and a lot of Congratulations from us!! ~~ Prof. Isidro T. Savillo- President, ISMCBBPR
June 30, 2012- Announcing the Molecule of the Year 2011. Congratulations!!
~~News Item- Molecule of the Year 2011
~~Our congratulations to Dr. Kounosuke Watabe and his former research team at the Southern Illinois University School of Medicine for their exemplary work on BMP7!!
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| 2010 | |
 | Forkhead Box Protein M1
E Gemenetzidis, D-E Costea, EK Parkinson, A Waseem, H Wan and M-T Teh.
Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1.
Cancer Res. 70(22), 9515-26. Click here for the announcement. Click here for the runners up
The A isoform of FOXM1 suppresses epithelial differentiation whereas in B&C upregulation predisposes cells to tumorigenesis by expanding stem/progenitor cell population. Therefore FOXM1 is a potential target for cancer therapeutics. |
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| 2009 | |
 | Sleeping Beauty Transposase SB 100X
Mátés L, Chuah MK, Belay E, Jerchow B, Manoj N, Acosta-Sanchez A, Grzela DP, Schmitt A, Becker K, Matrai J, Ma L, Samara-Kuko E, Gysemans C, Pryputniewicz D, Miskey C, Fletcher B, Vandendriessche T, Ivics Z, Izsvák Z.
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.
Nat Genet. 2009 Jun 41(6), 753-61 Click here for the announcement |
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| 2008 | |
 | anti-SAG 421-433 catalytic IgA
Stephanie Planque, Yasuhiro Nishiyama, Hiroaki Taguchi, Maria Salas, Carl Hanson and Sudhir Paul Catalytic antibodies to HIV: Physiological role and potential
clinical utility
Autoimmunity Reviews 7, 473-479 Click here for the announcement |
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| 2007 | |
 | PKD2L1
Yoshiro Ishimaru, Hitoshi Inada, Momoka Kubota, Hanyi Zhuang, Makoto Tominaga and Hiroaki Matsunami Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor
PNAS 103, 12569-12574 |
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| 2006 | |
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hsa-mir-155 and hsa-let-7a-2. (Primary)
Nozomu Yanaihara, Natasha Caplen, Elise Bowman, Masahiro Seike, Kensuke Kumamoto, Ming Yi, Robert M. Stephens, Aikou Okamoto, Jun Yokota, Ta
dao Tanaka, George Adrian Calin, Chang-Gong Liu, Carlo M. Croce and Curtis C. Harris.
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis Cancer Cell 9, 189-198
Supporting work
Peggy S. Eis, Wayne Tam, Liping Sun, Amy Chadburn, Zongdong Li, Mario F. Gomez, Elsebet Lund and James E. Dahlberg.
Accumulation of miR-155 and BIC RNA in human B cell lymphomas
PNAS 102, 3627-3632 |
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| 2005 | |
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4E10
Rosa M.F. Cardoso, Michael B. Zwick, Robyn L. Stanfield, Renate Kunert, James M. Binley, Hermann Katinger, Dennis R. Burtonand Ian A. Wilson.
Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41
Immunity 22, 163-173
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| 2004 | |
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Imidazoleacetic acid-ribotide
George D Prell, Giorgio P Martinelli, Gay R Holstein, Jasenka Matuli?-Adami?, Kyoichi A Watanabe, Susan L F Chan, Noel G Morgan, Musa A Haxhiu, Paul Ernsberger
Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors.
PNAS 101, 13677-13682
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| 2003 | |
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Adenovirus GP&NP of the Ebola Vaccine
Nancy J. Sullivan, Thomas W. Geisbert, Joan B. Geisbert, Ling Xu, Zhi-yong Yang, Mario Roederer, Richard A. Koup, Peter B. Jahrling and Gary J. Nabel
Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates
Nature 424, 681-684
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| 2002 | |
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All-Trans-Retinoic Acid
Sutisak Kitareewan, Ian Pitha-Rowe, David Sekula, Christopher H. Lowrey, Michael J. Nemeth, Todd R. Golub, Sarah J. Freemantle and Ethan Dmitrovsky
UBE1L is a retinoid target that triggers PML/RARα degradation and apoptosis in acute promyelocytic leukemia
PNAS 99, 3806-3811
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More detailed information about the winners of the Molecule of the Year will be added as this page is updated. Please send updates and corrections to the e-mail address indicated at the link on the top of the site.
Please be patient as we move into our new home on the web.
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