Our congratulations to Dr. Muy Teck Teh and his team for performing the seminal work on FOXM1 in 2010, which as a result is the Molecule of the Year 2010

The Publication
Gemenetzidis, E., D.-E. Costea, E.K. Parkinson, A. Waseem, H. Wan and M-T Teh. 2010. Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. Cancer Res. 70(22):9515-26.

Corresponding Author
Muy-Teck Teh, Centre for Clinical and Diagnostic Oral Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London

News Releases
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Queen Mary University of London

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Corresponding author
Muy-Teck Teh
What the voters say

FOXM1 suppresses epithelial  differentiation and predisposes cells to tumorigenesis by expanding stem/progenitor cell population- it is a potential target for cancer therapeutics.

[This molecule was chosen due to] the role it has in controlling the cell cycle in progenitor/stemlike cancer cells. This area of research is addressing some fundamental cell biological processes, and this molecule and studies around its function could have implications for the “cancer stem cell” hypothesis which is a fundamentally important, hotly debated topic for cancer biology.

[FOXM1 is] a promising raw material that will serve as a significant target for cancer prevention.


Further information about this molecule can be found at the Wikipedia page here